Flu and Virus Testing
Cayman Chemical ANTIBODY VP-14637 5mg
A PDE4 inhibitor (IC50 0.8 nM) selective for PDE4 over PDE1 -2 -3 and -5 (IC50s 10 10 10 and 8 UM respectively) inhibits fMLP-induced LTB4 production in isolated human neutrophils (IC50 2 nM) reduces the proliferation of anti-CD3 and anti-CD28-stimulated isolated human CD4 T cells (IC30 7 nM) prevents pulmonary inflammatory cell infiltration and emphysema in mice exposed to cigarette smoke at 5 mg/kg
Cayman Chemical SARS-CoV-2 nutralIzng ntIb 1ea
An ALK4 and ALK5 inhibitor (IC50s 113 and 343 nM respectively) selective for ALK4 and ALK5 over a panel of 467 kinases at 1 UM inhibits ALK4 or ALK5 signaling in a reporter assay using HEK293 cells expressing ALK4 or ALK5 (IC50s 526 and 245 nM respectively) inhibits TGF-B1-induced increases in the levels of phosphorylated Smad2 in C2C12 myoblasts at 1 or 10 UM induces valvular interstitial cell proliferation neutrophil infiltration hemorrhage and fibrin deposition in rat heart valves at 150 or 500 mg/kg per day
Cayman Chemical SARS-CoV-2 nutralIzng ntIb 1ea
A PI4KIIIa inhibitor (IC50 5.01 nM) selective for PI4KIIIa over PI4KB PI3Ka PI3KB PI3K and PI4KY (IC50s 1000 2512 7943 2512 and 2512 nM respectively) inhibits replication of HCV genotypes 1a 1b and 2a in a cell-based replicon assay (IC50s 12.6 2.51 and 12.6 nM respectively)
Cayman Chemical SARS CoV-2 Neutralizing Antib
A Y-secretase modulator selectively inhibits the production of AB42 in CHO cells expressing wild-type APP (IC50 9.8 nM) over Notch cleavage to NICD (IC50 >15.8 UM) decreases brain levels of AB42 in rats at 10 and 40 mg/kg decreases CSF levels of AB40 and AB42 and increases levels of AB38 and AB39 without affecting total AB CSF levels in dogs at 20 mg/kg
Cayman Chemical SARSCoV2 MaIn Protease InhI 96
A carbamate fungicide inhibits the production of aflatoxins in A. parasiticus (IC50 0.43 UM) inhibits wild-type B. cinerea and strobilurin-resistant B. cinerea mitochondrial complex II (IC50s 0.079 and 5.1 UM respectively) and wild-type B. cinerea mitochondrial complex III (IC50 0.023 UM) prevents and reduces B. cinerea lesion development on cucumber seedlings at 3 UG/ml inhibits B. cinerea mycelial growth (EC50 0.006 UG/ml)
Cayman Chemical SARSCoV2 SpIke Reagent120uL
A quenched fluorescent probe for GST activity can be used in adherent or suspension cells cell or tissue lysates or purified enzyme preparations upon deprotection by GSTs rhodamine 110 is released and its fluorescence can be quantified using ex/em maxima of 496/520 nm respectively
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
An activator of Nrf2 signaling increases the expression of Nrf2 target genes and activates HO-1 in CV-1 cells at 100 nM binds to PPARY and PPARa (Kis 344 and 232 nM respectively) and induces PPARY transactivation in SW480 cells inhibits NOS production in isolated mouse macrophages (IC50 0.014 nM) inhibits proliferation of U937 and MCF-7 cells at 300 nM reduces fatty acid synthesis in LiSa-2 human liposarcoma cells at 100 nM reduces tumor growth in a B16 murine melanoma model at 50 Ug/animal twice per day
Cayman Chemical SARSCoV2 nsp16 Methyltrnsf
An orally bioavailable ACE and NEP inhibitor (IC50s 1.7 and 5.3 nM respectively for the human enzymes) inhibits the angiotensin I-induced pressor response in normotensive rats (ED50 0.07 Umol/kg) lowers MAP in sodium-depleted spontaneously hypertensive rats at 30 Umol/kg lowers MAP in rats when co-administered with bradykinin increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner
Cayman Chemical SARSCoV2 SurfAC Glycoprote
ABAR agonist has been used as a standard for the simultaneous detection of multiple veterinary residues in commercial animal meat by LC-MS/MS
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
A MIF inhibitor a suicide substrate for MIF inhibits the migration and anchorage-independent growth of A549 NSCLC cells inhibits proliferation of and induces apoptosis in TPC-1 cells at 50 and 100 UM inhibits MIF tautomerase activity in mouse liver in vivo at 50 mg/kg
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
An ENPP1 inhibitor inhibits the hydrolysis of 23-cGAMP and AMP-pNP (Kis ≤100 and 100-1000 nM respectively in enzyme assays) enhances transcription of the gene encoding IFN-B in 23-cGAMP-stimulated HFF-1 cells
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
An ENPP1 inhibitor inhibits the hydrolysis of 23-cGAMP and AMP-pNP (Kis ≤100 and 100-1000 nM respectively in enzyme assays) enhances transcription of the gene encoding IFN-B in 23-cGAMP-stimulated HFF-1 cells
Cayman Chemical SARSCoV2 SpIk Glycoprotin 50uL
A σ receptor ligand with anticancer and antiviral activites binds to σ1 and σ2 receptors (Kis 13 and 0.28 nM respectively in MCF-7 cell membranes) selective for σ1 and σ2 receptors over hERG channels (Ki 1000 nM) inhibits growth of MCF-7 and multidrug-resistant MCF-7/adr cells (IC50s 25 and 15 nM respectively) decreases basal P-gp levels in the same cells reduces SARS-CoV-2 infectivity in Vero E6 cells (IC90 278 nM)